Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.

[1] Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2).

Treatment with hydrazine forms its hydrazide (3).

Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).

[2][3][4] This drug article relating to the gastrointestinal system is a stub.