At the University of Pennsylvania, his research focused on high-energy particle experiments at the energy frontier, with an interest in testing fundamental symmetries and studying the heaviest quarks.

[3] From 2002 to 2004, Lockyer served as co-spokesperson for a 600-person international collaboration known as CDF, the Collider Detector at Fermilab experiment at the laboratory's Tevatron particle accelerator.

[4] Under Lockyer's leadership, TRIUMF framed an ambitious vision to achieve a world-class program in rare-isotope beams and subatomic-physics research, to address some of the most fundamental questions in science.

This vision included expanding the nuclear-medicine program and the formulation of ARIEL, a new flagship facility for the study of isotopes for physics and medicine.

He also developed a strong working partnership among Canada's major science laboratories, expanded the number of member universities, and built international collaborations with Japan, India, China, and Korea.

As Fermilab director, Lockyer oversees a powerful complex of particle accelerators and sophisticated experiments to study the nature of matter, energy, space and time.

All three detectors will work in unison to search for sterile neutrinos and to advance liquid argon Time Project Chamber technology which has been adopted by DUNE.

[8] LBNF would be the most powerful tool in the world to study neutrinos and has been identified by the U.S particle physics community as the highest priority domestic construction project.

In order to supply the required intense bean of neutrinos to the detectors at the new and far sites Fermilab has proposed the Proton Improvement Plan II (PIP-II).

The proposed upgrade to the linear accelerator involves an international collaboration with India, whose Department of Atomic Energy will contribute hardware in exchange for experience in building high-intensity superconducting radio-frequency proton linacs.

In March 2015, a team of researchers using data collected during the first year of the survey discovered a rare dwarf satellite galaxy orbiting the Milky Way.