Nightmute (Central Yupik: Negtemiut or Negta[3]) is a city[4][5] and village in Bethel Census Area, Alaska, United States.

In 1964, many of its residents relocated by dogsled and founded the bayside community of Toksook Bay about 15 miles (24 km) downriver.

[3][9] The relocation was to avoid the yearly spring-winter migration to and from Umkumiut and Nightmute.

Nightmute lies 15 to 17 miles east of the neighboring village of Toksook Bay.

The racial makeup of the city was 91.83% Native American, 5.29% White and 2.88% from two or more races.

[13] Nightmute is the setting of the 2002 Christopher Nolan film Insomnia, starring Hilary Swank, Al Pacino, and Robin Williams.

The film was not shot in the real Nightmute, but Squamish, British Columbia.