Nipekamew Creek is a river in the boreal forest[1] ecozone in the Canadian province of Saskatchewan.

Its source is in muskeg approximately 20 kilometres (12 mi) west of Piprell Lake, near Highway 913.

[2] From the muskeg, the creek flows in a northerly direction through forests, rolling hills, glacier formed valleys, first into Stuart Lake,[3] then Nipekamew Lake.

Brook trout have been introduced to 25 rivers in the Cub Hills with five of those rivers now supporting populations of naturalised, self-sustaining feral brook trout.

All seven of Saskatchewan's trout species can be found in the Cub Hills.