The river's source is Nipekamew Lake at the north-western edge of the Cub Hills[2] and its mouth is in Nipekamew Bay at the southern shore of Lac la Ronge.

From the northern tip of Nipekamew Lake, the river travels from south to north through muskeg and boreal forest[3] en route to Lac la Ronge.

Adjacent to the mouth of the river is Fox Point Indian Reserve.

The upper reaches of the river's watershed include East Trout Lake, tributaries from the hills of Clarence-Steepbank Lakes Provincial Park,[4] Nipekamew Creek, and tributaries from the Cub Hills.

The cliffs can be accessed from a 1.5-kilometre (0.93 mi) hiking trail that starts off of Highway 165.