Yamaguchi completed her doctoral thesis in conjunction with translational labs at the MD Anderson Cancer Center in Houston, United States.

[4] Dr. Yamaguchi became known internationally for her strong activity to approve the WHO-supported Framework Convention for Tobacco Control, which ended up in Brazil adopting an indoor tobacco-free environment and many other regulations to prevent cancer and protect people of non-communicable chronic degenerative diseases.

Her work has addressed diversity, equality, and inclusion in the prevention and health quality of life issues, with a strong commitment to access of right and timely basis treatments, especially in cancer and non-communicable chronic diseases for low- and middle-income populations throughout the world.

Dr. Yamaguchi has written a book named The Human being facing cancer and the will to cure, nominated for the Jabuti Prize, and is in the second edition by UNESP editors.

During the Covid-19 health emergency in Brazil she allegedly took part in a shadow cabinet to advise then president Jair Bolsonaro, advocating for the use of hydroxychloroquine and other drugs without proven efficacy in early-stage Covid-19 cases, as well as for the easing of the social distancing measures in order to accelerate herd immunity, which she and other doctors thought would end the pandemic.

The Holocaust is an extremely important moment for us, where 6 million Jews were killed, and many survivors contributed to the foundation of our hospital.” The Sao Paulo Jewish federation also condemned Yamaguchi, saying her remarks “minimize the horrors of Nazism and offend the memory of victims, survivors and their families.” Yamaguchi apologized on Sunday, saying her comments were not anti-Semitic, paying tribute to her late Jewish mentor, and recalling her support for her sister’s conversion to Judaism.