It was developed and marketed for the United States and Canada, where Nissan had not previously been present in the full-size segment.

The NV used the same F-Alpha platform as does the Nissan Titan full-size pickup, but due to the need for a flat loading floor it is highly modified and they end up sharing mainly powertrain pieces and some of the design language.

[3] The NV1500 has a load capacity of 2,590 lb (1,175 kg), similar to the GMC/Chevrolet cargo van using the same "1500" designation, and informally known as a "half-ton".

The SV trim featured a lockable center console with power outlets as well as an additional 120 V outlet in the cargo compartment along with the features from the 1500 SV, while the SL trim added chrome bumpers, grille, and door handles and 17" chrome wheels.

The NV3500 HD was the heaviest weight class offered, and was only available with the large 5.6-litre V8 engine with either a low or a high roof.