The Nkusi River is in the Bunyoro sub-region, in the Western Region of Uganda.

It flows in a north-westerly direction to enter a swamp near the village of Kitoma, in the Kibaale District.

The river emerges from this swamp and flows westwards to empty into Lake Albert at the border with the Democratic Republic of the Congo.

The source of the Nkusi River is in Kakumiro at Latitude 0.7955 N, Longitude 31.2190 E.[1] The river enters Lake Albert at Kigwabya in Kibaale District at Latitude 1.1195 N, Longitude 30.6670 E.[2] At its source, the altitude is approximately 1,334 metres (4,377 ft).

[3] At its point of entry into Lake Albert, the altitude is approximately 616 metres (2,021 ft).