The district headquarters at Kibaale are approximately 219 kilometres (136 mi), by road, west of Kampala, Uganda's capital and largest city.

The administration of the Lost Counties as well as Bunyoro itself was modelled on the Buganda political system and under the leadership of Baganda chiefs.

[6] In July 2012, an outbreak of Ebola virus disease was reported in Kagadi, and as of 14 August 2012 had infected 24 and killed 16, a 66 percent case fatality rate.

The government, the World Health Organization, and the U.S. Centers for Disease Control and Prevention sent experts to tackle the outbreak.

The district, like most of the Western Region, is a predominantly rural area, with an average population density of around 145 square kilometres (56 sq mi).