It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.

[2] Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture.

[3] Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.

[4] Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer[5].

[5] Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer.