[1] The first total synthesis of ochnaflavone derivatives was achieved by Kawano group in 1973, followed by the Heerden group for the first time reporting the total synthesis the ochnaflavone by constructing a diaryl ether intermediate and assemble the two flavone nuclei through ring cyclization.

Find molecules that possess anti-proliferation activity of vascular smooth muscle cells seems a good strategy to treat Atherogenesis.

In 2006, a research group from Korea found Ochnaflavone could inhibit tumor necrosis factor (TNF)-a-induced human vascular smooth muscle cells proliferation.

It was achieved by the ability of Ochnaflavone to regulate the extracellular signal-regulated kinase 1/2, matrix metalloproteinase-9 and cell cycle.

Phospholipase A2 (PLA2) is important in many inflammatory processes as it catalyses the release of arachidonic acid, which could generate lipid mediators of inflammation.