[3] During the 18th and 19th centuries, the area now occupied by Noble County was used as a hunting ground by the Osage Indians.

Later, reservations were created in the northeastern part of the county for the Otoe and Ponca tribes.

After the 1893 opening of the Cherokee Outlet for settlement by non-Indians, the land was divided into counties.

The town of Perry was laid out in August 1893 as the county seat and land-office town[3] Oklahoma City bomber Timothy McVeigh was arrested in Noble County April 19, 1995, heading north bound on Interstate 35.

He was minutes from being released when the Noble County Sheriff's Department was notified to hold McVeigh.

McVeigh's arresting officer, Charlie Hanger, was elected Noble County Sheriff in 2004.

[4][5] In 2010, the Keystone-Cushing Pipeline (Phase II) was constructed north to south through Noble County.

[3] Ditch Witch, a Charles Machine Works company, is headquartered in Perry, the county seat.

The following sites in Noble County are listed on the National Register of Historic Places: