The Nogales Arizona Port of Entry on Grand Avenue has been in existence since the early 20th century.

The border station was completely rebuilt in 1966 and upgrades to the pedestrian gates were made by the General Services Administration in 2012.

[1] It is one of three border crossings in Nogales; the Nogales-Mariposa Port of Entry, built in 1973, handles commercial traffic west of the Grand Avenue crossing, while the adjacent Nogales-Morley Gate Port of Entry is used for pedestrians.

In 1931, as part of a nationwide program to improve border security during Prohibition, The border fence was improved and two small inspection bungalows, which local residents termed "garitas", were constructed at portals on Grand Avenue and Morley Avenue.

The Grand Avenue garita was expanded substantially in 1949, but was replaced with the current multi-lane inspection facility in 1966.