Noko Alice Matlou (born 30 September 1985) is a South African professional soccer player who plays as a defender for Spanish Primera Federación side CP Cacereño Femenino.

[3] In August 2024, she signed a 1-year contract with Primera Federación side CP Cacereño Femenino.

[5] In September 2009, Matlou was subjected to a gender "inspection" by a referee in the presence of the opposition captain, before South Africa's match against Ghana at Caledonian Stadium, Pretoria.

[6] Matlou came to prominence within the national team by scoring six goals at the 2008 African Women's Championship.

[5] She has been selected for the squads for a variety of tournaments, including at the 2012 Summer Olympics in London, United Kingdom.