[1] On 16 April 2019, it was announced that Seoposenwe had signed her first professional contract with Gintra Universitetas in Lithuania, joining them to play in the 2019-20 UEFA Women's Champions League season.

Seoposenwe signed for Spanish side Real Betis Balompie on 8 February 2020, making her debut in a 2–1 victory over RC Espanyol the following weekend.

On 23 March 2022, SC Braga won the Taca da Liga on penalties against SL Benfica with Seoposenwe playing the entire 120 minutes.

On 18 October 2015, Seoposenwe scored the winning goal against Equatorial Guinea which secured South Africa's qualification to the 2016 Summer Olympics in Rio de Janeiro.

[12] The result qualified South Africa for the 2019 FIFA Women's World Cup for their first appearance at the competition, with Seoposenwe part of the 23 player squad for the tournament in France.