The film revolves around a curse brought on by the kumakatok, an enigmatic being from Filipino folklore characterized by their tall, thin and long pale fingers, and by wearing veils that obscure their faces.

At the heart of the story lies Jamie (Nadine Lustre), the daughter, who made the difficult decision to leave her family behind and pursue a life overseas.

Nokturno is Red and Lustre second collaboration after having worked together on the hit techno-horror film Deleter (2022).

[6] In February 2023, it was reported that Nadine Lustre would be taking on the lead role with director Mikhail Red's new upcoming film, Nokturno.

[7] As the film gears up for production, it was further announced on August 7, 2023, that Lustre would be joined by another cast, including Bea Binene, Wilbert Ross and seasoned actress Eula Valdez.