Noncoding RNA Activated by DNA Damage

[2] By sequestering the PUMILIO proteins, NORAD allows the involved mRNA (pieces of genetic information derived from DNA that act as protein-coding messengers), to exert their function and maintain many cellular processes.

[7][9][10] Specifically, miRNAs are short RNAs that bind to their target mRNAs and lead to their degradation or inability to produce encoded proteins.

[7] NORAD levels are seen to be elevated in the fluid component of blood (serum) of patients suffering from Rheumatoid arthritis (RA), an autoimmune disorder that causes deformities in the joints.

[11] These elevated NORAD levels are positively correlated to other inflammatory markers such as C-reactive protein (CRP), rheumatoid factor (RF), and erythrocyte sedimentation rate (ESR).

[12] This was seen in mice who were missing NORAD through visible aging signs such as hair loss (alopecia), grey fur, and abnormal caving-in of the spine (kyphosis) by 12 months old.