It is defined as an antibody against the Fc portion of IgG and different RFs can recognize different parts of the IgG-Fc.
[1] RF and IgG join to form immune complexes that contribute to the disease process such as chronic inflammation and joint destruction at the synovium and cartilage.
There are different methods available, which include nephelometry, turbidimetry, agglutination of gamma globulin-coated latex particles or erythrocytes.
[citation needed] It is also found in Epstein–Barr virus or Parvovirus infection and in 5–10% of healthy persons, especially the elderly.
There is an association between rheumatoid factor and more persistently active synovitis, more joint damage, greater eventual disability and arthritis.