In Brick, which won the Special Jury Prize for Originality of Vision at the 2005 Sundance Film Festival, Zehetner plays the femme fatale Laura.

The soundtrack CD of this film, released by Lakeshore Records on March 21, 2006, features Zehetner's full, unedited performance of "The Sun Whose Rays Are All Ablaze".

[1] Together with the actors and comedians Tom Arnold and Dax Shepard, Zehetner embarked in 2007 on a USO/Armed Forces Entertainment tour to the Persian Gulf region to meet with service members and sign autographs.

[3] Zehetner portrayed the recurring role of Dr. Reed Adamson for 10 episodes during the sixth season (2009–2010) of the television series Grey's Anatomy.

[4] In 2018, Zehetner was cast in the recurring role of Valeria Poriskova on the second season of the ABC political drama Designated Survivor.