North Carolina Highway 61 (NC 61) is a primary state highway in the U.S. state of North Carolina.

It serves as the main north–south highway in eastern Guilford County, connecting Whitsett and Gibsonville.

Serving primary as a farm-to-market, it connects the farms in eastern Guilford County with Whitsett and Gibsonville.

[2] In 1936, NC 61 was extended northeast to US 70, near Whitsett.

In 1940, NC 61 was truncated at its current southern terminus, its former routing south to Thomasville replaced by NC 62.