North Carolina Highway 22 (NC 22) is a North Carolina state highway that runs in the central-north region of the state.

It heads north along Central Drive and then runs independently after the roundabout at Airport Road.

NC 22 then runs concurrent with US 15/US 501 for about 1 mile (1.6 km) before entering Carthage from the south.

It meets US 64 and runs concurrent with it along Jordan Road before heading west through Franklinville.

The route continues north until it reaches its northern terminus at the junction of NC 62 in Climax.