In 1943, what is now called the South Building was completed and North Side was formed with the consolidation of Huntersville, Pope, Fairview, Browns Church, and Spring Creek schools.

East High consolidated with North Side in 1970, and Beech Bluff in 1977.

In 1992, Jackson City and Madison County school systems were combined.

List of individuals having served as Principal of North Side High School: 1944–1950: C. J. Huckaba 1950–1962: M. G. Anderson 1962–1986: Thurman Reynolds 1986–1992: O'Neal Henley 1992–1995: Clarence Boone 1995–1996: Dan Shaw 1996–2004: Lora Murchison (First female high school principal in Jackson-Madison County) 2004–2007: Mike Martin 2007–2008: Buddy White 2008–2012: Jan Watson 2012–2014: Ricky Catlett 2014–2022: Jason Bridgeman 2022– : Dr. Bryan Chandler The school mascot is the Indian.

The stadium is also known as "The Reservation", it is dedicated and named after long-time North Side coach, T.D.