The station primarily serves the larger city of Santa Maria, located 8 miles (13 km) to the east.

Guadalupe station is served by four Amtrak Pacific Surfliner trains (two in each direction).

[3] In Fiscal Year 2023, 10,099 passengers boarded or detrained at Guadalupe station.

The new station was built in a Spanish Colonial Revival style featuring a barrel red-tiled roof and white stuccoed walls, similar to that of older train stations in Southern California.

Media related to Guadalupe station (Amtrak) at Wikimedia Commons