[2] Northwest has a large selection of Advanced Placement courses, English Language, English Literature, Seminar, Statistics, Calculus AB, Calculus BC, Computer Science principles, Biology, Chemistry, Physics I & II, Environmental Science, Government & Politics, World History, Psychology, US History, Human Geography, African American Studies, Latin, German, Spanish, Studio Art-Drawing, Studio Art-2D.

Students may take additional online courses through the North Carolina Virtual Public School,[3] and can take dual enrollment courses as part of the Career and College Promise program at Guilford Technical Community College.

[4] Northwest Guilford High School is a member of the North Carolina High School Athletic Association (NCHSAA).

About 15% of the student population participates in at least one of the band programs offered.

[citation needed] Concert bands The school's theatre department is home to the International Thespian Society's Troupe 8010.