The hospital is a division of Northwestern Medicine since 2018 when Northwestern Medicine partnered with Centegra Health System.

In 1914, a group of physicians obtained a charter for a hospital in the home and office of Hyde West.

The success of this hospital was such that a second hospital was built on South Street in the city.

The hospital was named Centegra Hospital - Woodstock until 2018 when it was renamed Northwestern Medicine Woodstock Hospital after Northwestern Medicine's takeover.

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