A settlement has been reported to exist in Nosedo since the Middle Ages, when the Goths controlled the Milanese.

The oldest reference to the name "Nosedo" (then Nosea) is found in a document dating back to 1346.

During Napoleonic rule (1806–1816), Nosedo was annexed to Milan, to return to its autonomy when the Kingdom of Lombardy–Venetia was founded.

Some of these cascine have been illegally occupied by homeless and Romani nomads, and friction between these and the local population has occurred, especially between 2006 and 2008.

In 1998, an association was founded with the mission of preserving the church and the cascina and, in general, the historical and religious tradition of Nosedo.