Hôpital Notre-Dame is a general hospital offering a range of services to the local community including a 24-hour emergency department, radiology (MRI, CT scan, Radiography, and Ultrasound), day medicine (blood test center, nursing services), cardiology, electrophysiology, neurology, ENT, audiology, ophthalmology, gynecology, occupational therapy, physiotherapy and pediatrics.

The secretary of Université Laval à Montréal, Dr. Emmanuel Persillier-Lachapelle, was given the mandate to establish the new health institution, assisted by the Sulpician Victor Rousselot, parish priest of Notre-Dame, as well as Mother Julie Haineault-Deschamps, of the Congregation of the Grey Nuns.

[citation needed] In the late nineteenth century, Hôpital Notre-Dame became one of the largest hospitals in the country, with six specialized departments: general practitioners, surgery, psychiatry, otolaryngology, ophthalmology and electrotherapy.

On 14 June 1934, the internes at Notre-Dame commenced Canada's first medical strike to protest the appointment of a "Hebrew", Dr. Sam Rabinovitch, to the staff.

Funds for the new Jewish General Hospital were obtained through charitable drives headed by Allan Bronfman, Sir Mortimer Davis and J.W.

It was designated as a National Historic Site of Canada on November 23, 1997 in commemoration of the growing professionalism of nursing and the expanding role of women in health care.