Notre Dame College Preparatory is a male-only Roman Catholic secondary school founded in Niles, Illinois, in 1955 by the Congregation of Holy Cross.

Notre Dame College Prep was one of the first Catholic high schools to open in the suburban Chicago area.

It was opened at the request of the then Cardinal Archbishop of Chicago, Samuel Stritch, with the supervision of the Priests of the Congregation of Holy Cross.

An excerpt from the Congregation's Province Review in 1954 noted:[4] For years the University (of Notre Dame) and the Community have been helped by a large group of loyal friends in the Chicago area.

[7] The Burke Scholar Program is for students with developmental and learning disabilities who are below grade level but can function in a classroom without 1:1 support.

[9] Notre Dame College Prep sponsors teams in 15 sports that are governed by the Illinois High School Association: baseball, basketball, bowling, cross country, football, golf, soccer, swimming & diving, tennis, track and field, volleyball, and wrestling.