[3] The original school, St. Patrick Academy, was opened by the Christian Brothers near Adams Street and Des Plaines.

The student population was bigger than anticipated, which required almost immediate addition to the new structure; a construction project completed for the 1956–57 school year, which became known as the "Round Building" due to its cylindrical shape.

Saint Patrick currently offers 3 levels of courses: College Prep, Honors, and AP or Dual Credit.

The chess team has had multiple state tournament appearances, and has developed a friendly rivalry with St. Ignatius College Prep.

The school participates in the East Suburban Catholic Conference (ESCC) for most of their sports, which include baseball, basketball, bowling, cross country, football, golf, soccer, swimming & diving, tennis, track & field, volleyball, water polo, and wrestling.

A young Ray Meyer, famous DePaul University men's basketball coach, lead the Shamrocks with 12 points.

St. Patrick defeated Leo High School 47-35 securing them their first Chicago Catholic League title.

St. Patrick had to play Tilden High School, the Chicago Public League champion, for the City Championship.