[2] During mRNA export, the nuclear cap-binding protein complex recruits ribosomes to begin the pioneer round of translation.

Human nuclear cap-binding protein complex shows the large subunit, CBP80 consists of 757 amino acid residues.

The conformational change results from a hinge-like motion of the N terminus from the alpha helixes in the α2–α3 loop towards the β-sheets.

[5] In some instances, the nuclear cap-binding complex is replaced by eIF4E in a translation-independent manner in order to continue translation of the mRNA.

[6][9] It is thought that the CBP80 subunit could be an effector of the pioneer stage since the binding of the nuclear cap-binding protein complex to the cap site is stimulated by growth factors during the G1/S phase.

[7] The nuclear cap-binding complex has a larger role in mRNA quality control than it does in actual protein synthesis.

Nonsense-mediated decay is when faulty mRNA's that have stop codons too early are recognized by the SURF complex and down-regulated.

[3][7] Nonsense-mediated decay is thought to be triggered when the first ribosome that translated a new nuclear cap-binding protein complex-bound mRNA has a stop codon that is found more than 50-55 nucleotides upstream of an exon-junction complex-bearing exon-exon junction.