The Zone is bordered by South Sudan, on the Northern Baro River, Western Piwbör, and Southwestern Pibor River, on the east by Itang Special Woreda, and on the South-East by Anuak Zone.

Nuer Zone is within the Ethiopian lowlands and is relatively flat at an elevation between 400–430 meters above sea level.

[1] Both Jikawo and Akobo woredas are flooded during the rainy season, requiring the people to migrate to the highlands with their cattle until the waters recede; thus raising livestock is the primary source of income in this Zone.

[2] Based on the 2007 Census conducted by the Central Statistical Agency of Ethiopia (CSA), this Zone has a total population of 112,606, of whom 60,543 are men and 52,063 women.

The largest group of the inhabitants said they were Protestant, with 88.82% of the population reporting they embraced that belief, while 5.7% practiced traditional religions, 5.3% were Muslim, 3.26% were Catholic, and 1.44% professed Ethiopian Orthodox Christianity.