The first salmon cannery in the Bristol Bay region was constructed by Arctic Packing Company in 1883 at Kanulik, just east of Nushagak Point.
The Pacific Steam Whaling Company built a cannery there in 1899 with Crescent Porter Hale as its first superintendent.
Pacific American Fisheries bought the property in 1933 along with others in the region but never operated the Nushagak cannery.
The world wide influenza pandemic of 1918 devastated the region in 1919, and contributed to the depopulation of Nushagak.
After the epidemic a hospital and orphanage were established in Kanakanak, across the river and 6 miles (10 km) from the present-day city center of Dillingham.
Nushagak first reported on the 1880 U.S. Census as an unincorporated village (spelled "Nushegak" and with the alternative name of "Alexandrovsk.