[1] From its source at Tikchik Lake, an extension of Nuyakuk Lake in Wood-Tikchik State Park, it flows eastward into the larger river upstream of Koliganek.

[3] The Nuyakuk's mouth is 65 miles (105 km) northeast of Dillingham.

"[4] The segments of the Nuyakuk that require portages occur along the upper 7 miles (11 km) of the stream below Tikchik Lake.

Beyond these rapids and ledges, the river is Class I (easy) all the way to the mouth.

[4] Game fish inhabiting the Nuyakuk include rainbow trout, char, Arctic grayling, silver salmon, king salmon, and lake trout.