The coordinates of Nyakayojo Division are Latitide: 0° 38' 1" (0.6336°) south Longitude: 30° 36' 47" (30.6131°) east Average elevation: 1,422 meters (4,665 feet) Nyakayojo Division borders with Isingiro District and Nyamitanga Division in the East, Bubaare subcounty of Mbarara District in the North, Kakiika Division in the Northeast, Mwizi subcounty in the South, Bugamba and Rugando subcounties of Rwampara District in the west.
[1] The Mbarara Kabale road transverses through Nyakayojo.
The division is a home to a famous secondary school called Nyakayojo Secondary School, Karama Catholic community and a home area of Angella Katatumba.
Nyakayojo Division contains the following neighborhoods, Kicwamba, Katojo, Rwakishakizi, Bugashe, Nyakayojo hill, Katukuru, Kisoro, Rwariire, Kibona, Katereza and Rukiindo.
The 2002 population census established the population of Nyakayojo as 29,396, In 2009 Uganda National Bureau of Statistics estimated the population to be 34,000, the 2014 National population and Housing Census found the population of Nyakayojo Division at 38,252 people.