There are a number of inhabited places close to the banks of the river, including Ust-Urkima, Lopcha, Chilchi, Ust-Nyukzha, Larba and Yuktali, mostly with a significant Evenk population.

[5] There are rock paintings of the Early Iron Age by the right bank of the Nyukzha and 214 km (133 mi) from its mouth, near the confluence with the Onen river.

Its source is in Zabaykalsky Krai, in the northern slope of the Nyukzha ridge, a spur of the Urushin Range, of the Olyokma-Stanovik Highlands.

Farther downstream the Nyukzha slows down, divides into arms, and forms meanders.

Finally it joins the right bank of the Olyokma 187 km (116 mi) from this river's mouth in the Lena.