The Nzhelele River is a major watercourse in Limpopo Province, South Africa.

[2] This river collects much of the drainage of the northern slopes of the extensive rock formation of the Soutpansberg.

Leaving the mountainous area, it meanders in a northeastward direction across the Lowveld, a wide plain that contains considerable biodiversity, including numerous large mammals such as giraffes, white rhinos and blue wildebeests.

[3] It joins the right bank of the Limpopo River 33 km east of Musina.

[4] The Mutamba River, its main tributary, rises in the Buelgum Poort farm of the Soutpansberg, further west from the sources of the Nzhelele.