ONE Campaign (styled as ONE) is an international, non-partisan, non-profit organization advocating for the investments needed to create economic opportunities and healthier lives in Africa.

[2] ONE supports a broad variety of international development issues, including the fight against treatable and preventable diseases like HIV/AIDS, malaria, and tuberculosis; access to clean water and expanded access to energy; lessening corruption and improving transparency standards and government accountability to citizens; making trade fairer; providing basic education for all; and increasing international affairs budgets.

[23] The following people signed the open letter: Ali Hewson, Angelique Kidjo, Beyoncé, Charlize Theron, Christy Turlington, Danai Gurira, Helene Gayle, Lady Gaga, Lauren Bush, Mabel van Oranje, Dr. Maria Furtwangler, Meryl Streep, Michele Sullivan (president of the Caterpillar Foundation, director of Corporate Social Innovation), Naisula Lesuuda (senator, Kenya), Rita Wilson, Rosamund Pike, Sarah Silverman, Sheryl Sandberg, and Yvonne Chaka Chaka.

The event, which also marked ONE's 10 year anniversary, was hosted by The Daily Show's Trevor Noah and featured performances from Miley Cyrus, Hozier, Jessie J, Bono and The Edge.

[27] During 2015, ONE worked with partners at Action/2015 and Project Everyone to promote the new Global Goals for Sustainable Development around the world so citizens can hold leaders to account in delivering them by 2030.

[32] The campaign involved an open letter signed by several high-profile celebrity activists; including Meryl Streep, Oprah Winfrey, Amy Poehler, Tina Fey, Elton John, Colin Farrell, Mary J. Blige and Shonda Rhimes.

The song was released on all digital platforms and was met international acclaim, it featured artists from seven African countries, including 2Baba, Ben Pol, Teni, Yemi Alade, Amanda Black, Stanley Enow, Gigi lamayne, Prodigio, Betty G and Ahmed Soultan.

In partnership with TikTok, UNICEF, the WHO’s Viral Fact Africa, and the African Union, they launched an online quiz and interactive filter.

[37] Featuring some of Africa’s biggest celebrities and health experts, the campaign aimed to counter myths and inaccurate information, address ongoing fears and concerns, and raise awareness about the importance of COVID-19 vaccinations.

The animated stories were brought to life by a number of their celebrity activists Patrick Adams, Samuel Arnold, Bono, Connie Britton, Penélope Cruz, Meg Donnelly, Danai Gurira, Nick Kroll, Laura Marano, Kumail Nanjiani, David Oyelowo, Phoebe Robinson, Michael Sheen, Wanda Sykes, and Calum Worthy.

[39] Pandemica gained recognition for its impact, including at the 2022 Anthem Awards, winning Gold for Health and Best Strategy, as well as Silver for Campaign for Nonprofit.

"[43] ONE works with volunteer campaigners in different markets to raise awareness and lobby governments to fight extreme poverty and preventable disease.

ONE Youth Ambassadors are selected yearly from Ireland, the UK, France, Germany, the Netherlands, and Italy to support its grassroots mobilization and advocacy goals across Europe.

In the United States and Canada, ONE field organizers coordinate campaigning efforts, lobby members of Congress and Parliament, and host community awareness events.

ONE Campus chapters aim to teach students about extreme poverty and encourages members to campaign for lifesaving investments and US development policies.

2548; 113th Congress), a bill that would direct the President to establish a multiyear strategy to assist countries in sub-Saharan Africa develop an appropriate mix of power solutions to provide sufficient electricity access to people living in rural and urban areas in order to alleviate poverty and drive economic growth.

[49] ONE has worked with Publish What You Pay and a coalition of other non-government organisations[50] around the Cardin-Lugar Amendment and the passing of extractives transparency laws in the United States and Europe.

In June, Liberal Democrat MP Michael Moore used his Private Member's Bill to enshrine the law, making the UK the first G7 country to meet the UN spending target.