The house is 8,000 ft² and contains five-bedrooms and four-bathrooms in the classic Greek Revival-style architecture that was typical for plantation homes.

The heavily treed, rolling hills surrounding the compound are a diverse habitat for wildlife including whitetail deer, turkeys, quail and doves.

[3] Tallahassee's Old Floridan Hotel was the source of doors[4] and four huge 19th-century windows that were placed at the ends of the main hallways on each side of the first floor.

[2] The staircase off the grand foyer used pine from the Old Ormond Hotel which opened in 1888 and was built by Henry Flagler.

[5] There are formal living and dining rooms, a library with a comfortable reading area, a parlor with a wet bar, a chef's kitchen outfitted with high-end appliances plus an informal dining area; a separate caterer’s kitchen; a butler’s pantry, an office, a Home cinema featuring pediments and light fixtures once in the old Florida Capital building, and a screened porch overlooking the landscaped backyard.

[6] A three-car garage was built to resemble a carriage & tack house; a "gathering lodge" contains small living quarters, a workshop and equipment barn with three bays; a skeet-shooting area; an office/man cave; and a cooking shack for entertaining outside at the lodge.

In October 2003 the Wetherells announced the donation of Oak Hill Plantation to FSU after their deaths.

[8] After Wetherell resigned as FSU's president in 2010, the couple moved back to Oak Hill.