Ochridaspongia rotunda is a freshwater sponge endemic to Lake Ohrid.

Its circular shape indicates that the animal lives under conditions of relatively calm water.

Following comparative tests with positive controls of its extracts against 8 bacterial and 8 fungal strains, Ohridaspongia rotunda has been described as a potential "gold mine of new antimicrobial substances with significant and broad-range activity".

[2] Current research is investigating its acetone extracts for application in the treatment of Alzheimer's disease, for which it has demonstrated promising inhibitory activity.

[3] These may originate with symbiotic bacteria hosted by the sponge and further research is required.