Oestrich-Winkel (German pronunciation: [ˈøːstʁɪç ˈvɪŋkəl]) is a town with roughly 12,000 inhabitants in the Rheingau-Taunus-Kreis in the Regierungsbezirk of Darmstadt in Hesse, Germany.

Oestrich-Winkel was founded on the 1st of July, 1972 by the merger of the municipalities of Mittelheim, Oestrich and Winkel; it was further enlarged by incorporation of Hallgarten in 1977 by law.

The double-barrelled name Oestrich-Winkel has already had a long tradition as the name of the only train station for the East Rhine Railway between Geisenheim and Hattenheim.

The following places are cultivated: The Oestricher Kran, Oestrich-Winkel's main landmark, is a former wine-loading crane from the 18th century for loading and unloading ships.

On the town's northeast limit near Hattenheim stands Schloss Reichartshausen (founded in the 12th century) with its outbuildings, which about 1900 were remodelled to look like follies.

Karoline von Günderrode, a poet and one of Bettina's friends, stabbed herself here in Winkel in 1806 on the Rhine's bank out of lovesickness and life weariness.

The Rheingau Musik Festival has its office in Oestrich in a former winery, the presshouse (Kelterhalle) converted to a hall for intimitate concerts and events.