Its northern terminus is at State Route 283 (Lakeshore Boulevard) on the Timberlake/Eastlake border less than one mile (1.6 km) south of Lake Erie.

It becomes Darrow Road once again in the city of Stow and for its remaining length in Summit County, aside from within the Hudson city limits, where it is South and North Main Streets.

In Cuyahoga and Lake Counties, State Route 91 is known as SOM Center Road, named for the fact that it runs through the centers of the original Solon, Orange, and Mayfield Townships in Cuyahoga County.

[5] The State Route 91 corridor includes examples of Connecticut Western Reserve town planning, particularly the public squares of Hudson, Tallmadge, and Mayfield.

It also dissects several affluent communities of Northeast Ohio, including Hudson, Gates Mills, Pepper Pike, Hunting Valley, Moreland Hills and Solon .