After leaving the junction of U.S. Route 20, State Route 57 and State Route 301, where US 20 and SR 301 continue westbound on the freeway, SR 10 reaches North Ridgeville, where it merges with Interstate 480 at the interstate's western terminus in North Ridgeville, and continues with the interstate briefly eastward.

Just east of this junction, the route also has an interchange with Interstate 80 and the Ohio Turnpike via a connecting or spur road.

[10][11] In 1934, one year after SR 10 was not present, the route reappeared largely on its current alignment, running from Oberlin to downtown Cleveland.

[13][14] In 1988, SR 10 was truncated to its current western terminus after US 20 moved onto a freeway that was recently upgraded.

[15][16] In 2021, SR 10 was extended eastward to US 322 (Chester Avenue) in the University Circle neighborhood.