For much of its path, SR 110 runs generally parallel to the south of the Maumee River.

The highway crosses over the Maumee River and has an intersection with the southern end of the SR 108 concurrency.

SR 110 turns northeast, passing commercial properties as a four-lane undivided highway.

At a traffic signal with Appian Avenue the route narrows to a two-lane highway and parallels the Maumee River, passes through residential properties.

The concurrency heads east passing under railroad tracks owned by Indiana and Ohio Railway.

The route turns due east and passes through farmland, before its eastern terminus at an intersection with SR 65.

Also in that year the route was flipped US 24, once again putting SR 110 on the south banks of the Maumee.