The route was a former section of US 24 that ran parallel to the Maumee River and Miami and Erie Canal between the cities of Defiance and Napoleon.

Continuing northeast, the route made a sharp curve to the southeast and changed its name to West Third Avenue.

Shortly after passing under an Indiana Northeastern Railroad bridge,[1] the route came to a signalized intersection with South Clinton Avenue which also carries SR 111 in downtown Defiance.

After briefly traveling east to follow the river bank, the route turned north and entered the city limits of Napoleon.

[5][8] Since the decommissioning of the route, the intersection at the original western terminus in Defiance has become a folded diamond interchange, exit 22 off of the US 24 freeway.

[9] The dead end before the connector between the original US 24 freeway and the two-lane section east of Napoleon has been removed and is now a continuous route.

As the project to bring US 24 up to freeway standards between Fort Wayne, Indiana and Toledo progressed, the SR 424 designation was removed and the road transferred to county engineer departments and cities.