A few realignments of the route have happened; the first in 1927 removed a section of highway west of SR 49.

This section was later extended due west of SR 49 to the Indiana state line.

The road heads north along the state line passing through farmland as a two-lane highway.

In downtown Paulding, the road has a traffic signal at US 127 and the two routes head north concurrent.

The road enters Defiance on the southwest side of town, passing through residential properties.

[11][12] SR 111 was first signed and paved in 1923 from the Indiana state line west of Payne to Defiance.

At Baltimore Street (former SR 424), the two truck routes turn northeast onto Holgate Avenue paralleling the Maumee River.

After heading through a residential neighborhood of the city, the road bends to the east and transitions to West Third Street.