U.S. Route 24 (US 24) is a United States Numbered Highway that runs from Minturn, Colorado, to Independence Township, Michigan.

From Baltimore Street to State Route 281 (SR 281) at the border of Defiance and unincorporated Noble Township, US 24 is a freeway.

The route continues northeasterly as a surface street through downtown Maumee and the western side of Toledo, where it turns into Telegraph Road and stays on it past the Michigan state line.

This rerouting was done to "alleviate safety concerns caused by the mixture of truck traffic and residential travel" along US 24's former routing.

[6] The conversion to an expressway, first proposed in 1969, was done due to the high number of road accidents along the old alignment, which comprised only two lanes and was frequently used by tractor-trailers.