The portion of SR 66 between Washington Avenue in Piqua and the Miami/Shelby County line is designated as the "Cpl.

Samuel F. Pearson Memorial Highway",[2] in honor of a Piqua High School graduate who was killed at Camp Victory in Baghdad, Iraq, while serving in the Army Reserve, on October 10, 2007.

Beginning at a signalized intersection with South Jefferson Avenue (SR 66), it heads west on Downs Street through a residential neighborhood.

At Baltimore Street (former SR 424), the two truck routes turn northeast onto Holgate Avenue paralleling the Maumee River.

After heading through a residential neighborhood of the city, the road bends to the east and transitions to West Third Street.