The southern terminus of SR 205 is at a four-way stop intersection in the village of Danville where it meets U.S. Route 62 (US 62).

The junction also doubles as the southern terminus of SR 514, which runs concurrently with SR 205 for approximately one-quarter mile (0.40 km) heading north from there.

SR 205's northern terminus is at a T-intersection with SR 3 nearly six and a half miles (10.5 km) southwest of Loudonville.

Located entirely within the northeastern quadrant of Knox County, there is no portion of SR 205 that is inclusive within the National Highway System.

It has maintained the same northeastern Knox County alignment from its inception to this day.