The eastern terminus of State Route 219 is at a diamond interchange with Interstate 75 at its Exit 104 in Botkins.

Along its path, State Route 219 traverses portions of Mercer, Auglaize and Shelby Counties.

Outside of the towns, the route largely passes through agricultural areas mostly growing corn and soy.

[2] Stop signs, traffic lights, rail intersections, bridge crossings, accidents, wildlife, and farm equipment may or other slow-moving vehicles may cause delays, but generally traffic moves pretty steadily.

The designation was removed from what is now County Road 219A, and applied to what was a former eastern extension of SR 703 along the south side of Grand Lake Saint Marys between the Burge Road intersection and the Mercer-Auglaize County Line.