Now no longer bounded by the lake, SR 220 begins to climb in elevation again before turning to the east towards Waverly.

In the community of Greggs Hill, SR 220 passes under two railroad overpasses and makes an S-curve before continuing south.

For the remainder of the route, the route heads nearly due south east of Piketon and through Zahns Corner before ending at an intersection with the four-lane divided SR 32 and SR 124 (also called the James A. Rhodes Appalachian Highway).

[12][13] By 2013, SR 220's eastern terminus was moved to a location near its original southern terminus from 1923 when a portion of Schuster Road (CR 81) was taken over by the state between the Appalachian Highway and the intersection of SR 220 and Zahns Corner Road.

The route heads south along US 23 (Emmitt Avenue) before turning southeast onto Pride Drive, northeast onto West 2nd Street, and southeast onto Depot Street before ending at SR 220 south of downtown Waverly.